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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Publisher

Springer Vienna

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DOI

10.1006/enfo.2002.0088

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ISSN

1438-2199

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Synthesis of 4thia6Superscript13/Superscrip

Authors: Amarendra Nath Maity Ajam C Shaikh Sankareswaran Srimurugan ChiJu Wu Chinpiao Chen ShyueChu Ke
Publish Date: 2010/11/20
Volume: 42, Issue: 1, Pages: 309-315
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Abstract

4Thialysine S2aminoethyllcysteine is an analog of lysine It has been used as an alternative substrate for lysine in enzymatic reactions Sitedirected isotopomers are often needed for elucidation of mechanism of reactions 4Thialysine can be synthesized by reacting cysteine with 2bromoethylamine an important reagent in chemicalmodification rescue CMR of proteins Here we present the synthesis of 4thia613Clysine one of the isotopomers of 4thialysine from commercially available starting material 213Cglycine via formation of five intermediates including 2amino213Cethanol and 2bromo113Cethylamine The compounds were characterized using various spectroscopic techniques Moreover we discuss that our strategy would provide access to sitedirected isotopomers of 2aminoethanol 2bromoethylamine and 4thialysine Biological activity of 4thia613Clysine was tested in the enzymatic reaction of lysine 56aminomutase

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