Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Amino Acids

Search In Journal Title:

Abbravation: Amino Acids

Search In Journal Abbravation:

Publisher

Springer Vienna

Search In Publisher:

DOI

10.1007/bf01058371

Search In DOI:

ISSN

1438-2199

Search In ISSN:
Search In Title Of Papers:

Tissuespecific responses to loss of transglutamin

Authors: Stephanie Deasey Shobana Shanmugasundaram Maria Nurminskaya
Publish Date: 2011/12/23
Volume: 44, Issue: 1, Pages: 179-187
PDF Link

Abstract

Of the eight catalytic transglutaminases TGs transglutaminase 2 TG2 has been the most comprehensively studied due to its ubiquitous expression in multiple cell types Despite the observed critical role for this enzyme in multiple biological processes in vitro TG2 knockout mouse models have shown no severe developmental phenotypes suggesting compensation by other TGs To begin characterization of the compensating mechanisms we analyzed total transamidating activity and expression patterns of all catalytically active TGs in seven different tissues/organs from wildtype and TG2 knockout mice Inhibitory analysis with TG2specific inhibitor KCC009 suggests that relative contribution of TG2 in total transamidating activity differs in various tissues Accordingly our data indicate tissuespecific mechanisms of compensation for the loss of TG2 including transcriptional compensation in heart and liver versus functional compensation in aorta kidney and skeletal/cartiagenous tissues On the contrary no compensation has been detected in skeletal muscle suggesting a limited role for the TG2mediated transamidation in normal development of this tissueWe would like to thank Dr Chaitan Khosla for providing us with the TG inhibitor KCC009 and Dr Robert Graham for providing us with TG2−/− mice This work was supported by NIH grants R01R01HL093305 R56DK071920 and R03AR057126 and a grant from Maryland Stem Cell Research Fund to M Nurminskaya

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Structural protein reorganization and fold emergence investigated through amino acid sequence permutations
  2. Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study
  3. Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer
  4. A fluorescence anisotropy-based assay for determining the activity of tissue transglutaminase
  5. Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct
  6. Strategies for comprehensive analysis of amino acid biomarkers of oxidative stress
  7. Regulation of intestinal protein metabolism by amino acids
  8. Free amino acid production during tomato fruit ripening: a focus on l -glutamate
  9. Bacterial signaling and adaptation
  10. Gas chromatographic determination and mechanism of formation of D-amino acids occurring in fermented and roasted cocoa beans, cocoa powder, chocolate and cocoa shell
  11. 2-(Phenylethyl)ammonium hydrogensquarate hemihydrate: crystal structure, solid-state IR-spectroscopic and theoretical characterization
  12. Direct one-step labeling of cysteine residues on peptides with [ 11 C]methyl triflate for the synthesis of PET radiopharmaceuticals
  13. Near infrared spectroscopy compared to liquid chromatography coupled to mass spectrometry and capillary electrophoresis as a detection tool for peptide reaction monitoring
  14. EPR spin-trapping of protein radicals to investigate biological oxidative mechanisms
  15. Kinetic study of racemization of aspartyl residues in synthetic elastin peptides
  16. Proteomics analysis of sensitive and tolerant barley genotypes under drought stress
  17. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression
  18. Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen–glucose deprivation-induced damage
  19. Cardiovascular actions of l -cysteine and l -cysteine sulfinic acid in the nucleus tractus solitarius of the rat
  20. Synthesis of 4-thia-[6- 13 C]lysine from [2- 13 C]glycine: access to site-directed isotopomers of 2-aminoethanol, 2-bromoethylamine and 4-thialysine
  21. The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects
  22. Selective regulation of polyamine metabolism with methylated polyamine analogues
  23. Circular dichroism and cross-linking studies of bacteriorhodopsin mutants
  24. LC/MS evaluation of metabolism and membrane transport of bombesin peptides
  25. Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): Overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5)
  26. Pitfalls in the synthesis of fluorescent methotrexate oligopeptide conjugates
  27. Regulation of apoptosis by protein S-nitrosylation
  28. Ethanol but not acetaldehyde induced changes in brain taurine: a microdialysis study
  29. Using the concept of Chou’s pseudo amino acid composition to predict protein subcellular localization: an approach by incorporating evolutionary information and von Neumann entropies
  30. WRF-TMH: predicting transmembrane helix by fusing composition index and physicochemical properties of amino acids
  31. Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni
  32. Acid-induced unfolding of didecameric keyhole limpet hemocyanin: detection and characterizations of decameric and tetrameric intermediate states
  33. Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?
  34. Dual effect of chloramphenicol peptides on ribosome inhibition
  35. Synthesis of C5-tetrazole derivatives of 2-amino-adipic acid displaying NMDA glutamate receptor antagonism
  36. Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development
  37. Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscle
  38. Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development
  39. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway
  40. Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
  41. Nardilysin in human brain diseases: both friend and foe
  42. Natural structural diversity within a conserved cyclic peptide scaffold
  43. Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis
  44. Positioning of aminopeptidase inhibitors in next generation cancer therapy
  45. Optimal and effective oral dose of taurine to prolong exercise performance in rat
  46. S-adenosylmethionine and its products
  47. Influence of l β-, d α- and d β-Asp isomers of the Asp-76 residue on the properties of αA-crystallin 70–88 peptide
  48. Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells
  49. Safety of long-term dietary supplementation with l -arginine in rats
  50. Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian d -aspartate oxidase
Search Result: