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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1007/s00028-003-0140-9

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ISSN

1438-2199

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Dopamine receptor antagonism disrupts social prefe

Authors: Tanya Scerbina Diptendu Chatterjee Robert Gerlai
Publish Date: 2012/04/11
Volume: 43, Issue: 5, Pages: 2059-2072
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Abstract

Zebrafish form shoals in nature and in the laboratory The sight of conspecifics has been found reinforcing in zebrafish learning tasks However the mechanisms of shoaling and those of its reinforcing properties are not known The dopaminergic system has been implicated in reward among other functions and it is also engaged by drugs of abuse as shown in a variety of vertebrates including zebrafish The ontogenetic changes in dopamine levels and to a lesser degree in serotonin levels have been found to accompany the maturation of shoaling in zebrafish Thus we hypothesized that the dopaminergic system may contribute to shoaling in zebrafish To test this we employed a D1receptor antagonist and quantified behavioral responses of our subjects using a social preference shoaling paradigm We found significant reduction of social preference induced by the D1R antagonist SCH23390 in the AB strain of zebrafish an alteration that was not accompanied by changes in motor function or vision We also detected D1R antagonistinduced changes in the level of dopamine DOPAC serotonin and 5HIAA respectively in the brain of AB zebrafish as quantified by HPLC with electrochemical detection We found the antagonistinduced behavioral changes to be absent and the levels of these neurochemicals to be lower in another zebrafish population SF demonstrating naturally occurring genetic variability in these traits We conclude that this variability may be utilized to unravel the mechanisms of social behavior in zebrafish a line of research that may be extended to other vertebrates including our own species

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