Authors: Roberta Galeazzi Gianluca Martelli Eleonora Marcucci Mario Orena Samuele Rinaldi Roberta Lattanzi Lucia Negri
Publish Date: 2009/07/08
Volume: 38, Issue: 4, Pages: 1057-1065
Abstract
An efficient route was developed for the synthesis of the Fmocprotected dipeptide 4 isostere of GlyGly containing an αmethylene βamino acid the conformationally restricted analogues of Leuenkephalin 3a and Metenkephalin 3b respectively were prepared by changing 4 for Gly2Gly3 in the native compounds 3a and 3b whose biological activities were significantly lower than the parent compounds
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