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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer-Verlag

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DOI

10.1002/chin.199929073

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1438-2199

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Optimal and effective oral dose of taurine to prol

Authors: T Miyazaki Y Matsuzaki T Ikegami S Miyakawa M Doy N Tanaka B Bouscarel
Publish Date: 2004/10/22
Volume: 27, Issue: 3-4, Pages: 291-298
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Abstract

The aim of this study was to determine the effective and optimum dose of taurine for exercise performance and to maintain tissue taurine concentration Rats received a respective daily dose of 0 20 100 and 500 mg/kg body weight of taurine EC and ET1 2 3 groups respectively for two weeks and then were subjected to treadmill until exhaustion The running time to exhaustion was significantly prolonged by 25 and 50 in the ET2 and 3 groups respectively compared to that in the EC group accompanied with maintenance of taurine tissue concentrations Furthermore the oxidative glutathione per total glutathione ratio in tissues was inhibited in the ET2 and 3 groups whereas it was higher in the EC group than in both the no exercise and taurineadministered groups Therefore the effective and optimal doses of oral taurine administration for two weeks on a transient exercise performance were between 100 and 500 mg/kg/day


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