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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1007/bf00953003

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ISSN

1438-2199

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Comparison of tissue transglutaminase 2 and bone b

Authors: Chiara Tarquini Rosanna Mattera Francesca Mastrangeli Sara Agostinelli Amedeo Ferlosio Roberto Bei Augusto Orlandi Umberto Tarantino
Publish Date: 2016/06/29
Volume: 49, Issue: 3, Pages: 683-693
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Abstract

Osteoporosis OP and osteoarthritis OA are the most common joint diseases with a high incidence in the elderly population OP is characterized by trabecular bone remodeling and reabsorption whereas articular cartilage and subchondral bone remodeling are major features of OA Although classically considered as independent or even conflicting processes clinical coexistence of OP and OA was recently described Transglutaminase 2 TG2 expression is considered a biomarker of OA but its role in osteoporotic bone remodeling is still uncertain We investigated TG2 and bone biological markers Osteocalcin Osteopontin and Sclerostin in osteoporotic and osteoarthritic osteocartilagineous tissue n = 54 and human chondrocyte cultures in vitro by immunohistochemistry immunofluorescence and RTPCR Histomorphometric evaluation of bone trabecular remodeling was also performed In cartilage TG2 expression was faint in control and OP and significantly less than in OA and OP + OA chondrocytes the opposite was found for Osteocalcin whereas Osteopontin and Sclerostin expression was similar In the subchondral trabecular bone osteocytes/osteoblasts TG2 expression was slight and similar comparing control OP OA and OP + OA group whereas Osteocalcin and Osteopontin expression was lower in OP compared to control OA and OP + OA Increased TG2 and reduced Osteocalcin expression were maintained in human osteoarthritic chondrocytes in vitro Histomorphometric analysis confirmed reduced trabecular bone mass in OP and OP + OA compared with OA patients TG2 represented a suitable biomarker of osteoarthritic chondrocyte activation whereas osteocalcin and osteopontin characterized osteoporotic osteocyte/osteoblast changes differences were lost in OP + OA patients suggesting careful consideration when coexistence of the two diseases occursThe authors acknowledge ASI Italian Space Agency and University of Rome “Tor Vergata” Spatial Biomedicine Center for partially founding this study number search DCDTE2011033 Thanks to S Cappelli for technical assistance and to M Feola and C Rao for collection of clinical dataAll procedures performed in this study involving human participants were in accordance with the ethical standards of the University of “Tor Vergata” Ethic Committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards Informed consent was obtained from all individual participants included in the study This article does not contain any studies with animals performed by any of the authors

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