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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1016/0013-4694(67)90018-1

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1438-2199

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Camphoric acid stimulates osteoblast differentiati

Authors: SuUi Lee Nam Sook Kang Yong Ki Min Seong Hwan Kim
Publish Date: 2008/11/25
Volume: 38, Issue: 1, Pages: 85-93
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Abstract

We found that camphoric acid significantly stimulated the differentiation of mouse osteoblastic MC3T3E1 subclone 4 cells as indicated by the induction of markers of osteoblastic differentiation To elucidate the mechanism of action of camphoric acid in osteoblast differentiation we evaluated the induction of transient receptor potential TRP cation channel family members and glutamate signaling molecules TRPM7 and TRPV1 were highly expressed but their expression was unaffected by camphoric acid Camphoric acid is structurally similar to glutamate receptor ligands and significantly induced the expression of NMDAR1 GluR3/4 and mGluR8 However camphoric acid exhibited weak regulatory activity toward glutamate receptors in a radioligand binding assay Camphoric acid also significantly induced the activation of NFκB and AP1 Together these data suggest that the stimulatory effect of camphoric acid on osteoblast differentiation was the result of its ability to induce mRNA expression of glutamate signaling molecules and to activate transcription factorsThis work was supported by grant No M108KH01001208K080101220 from the Center for Biological Modulators of the twentyfirst Century Frontier RD Program the Ministry of Science and Technology Korea We thank S Y Ryu and Y S Kim of the Laboratory of Phytochemistry Research Korea Research Institute of Chemical Technology for providing natural compounds for the preliminary study

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