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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1016/0167-2738(90)90484-9

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ISSN

1438-2199

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Vaspin attenuates the apoptosis of human osteoblas

Authors: Xiao Zhu Yi Jiang PengFei Shan Jie Shen QiuHua Liang RongRong Cui Yuan Liu GuanYing Liu ShanShan Wu Qiong Lu Hui Xie YouShuo Liu LingQing Yuan ErYuan Liao
Publish Date: 2012/11/08
Volume: 44, Issue: 3, Pages: 961-968
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Abstract

It has been hypothesized that adipocytokines originating from adipose tissue may have an important role in bone metabolism Vaspin is a novel adipocytokine isolated from visceral white adipose tissue which has been reported to have antiapoptotic effects in vascular endothelial cells However to the best of our knowledge there is no information regarding the effects of vaspin on osteoblast apoptosis This study therefore examined the possible effects of vaspin on apoptosis in human osteoblasts hOBs Our study established that vaspin inhibits hOBs apoptosis induced by serum deprivation as determined by ELISA and TUNEL assays Western blot analysis revealed that vaspin upregulates the expression of Bcl2 and downregulates that of Bax in a dosedependent manner Vaspin stimulated the phosphorylation of ERK and pretreatment of hOBs with the ERK inhibitor PD98059 blocked the vaspininduced activation of ERK however vaspin did not stimulate the phosphorylation of p38 JNK or Akt Vaspin protects hOBs from serum deprivationinduced apoptosis which may be mediated by activating the MAPK/ERK signaling pathwayThis work was supported by funding from The National Natural Science Foundation of China No 81270962 30801203 30871191 and 81070246 science and technology grant of Development and Reform Commission of Hunan Province 2011–1318 education science and technology grant of Department of finance of Hunan Province 2011–43

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