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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1016/0165-4896(95)96920-c

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ISSN

1438-2199

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Nardilysin in human brain diseases both friend an

Authors: HG Bernstein R Stricker H Dobrowolny J Steiner B Bogerts K Trübner G Reiser
Publish Date: 2013/04/19
Volume: 45, Issue: 2, Pages: 269-278
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Abstract

Nardilysin is a metalloprotease that cleaves peptides such as dynorphinA αneoendorphin and glucagon at the Nterminus of arginine and lysine residues in dibasic moieties It has various functionally important molecular interaction partners heparinbinding epidermal growth factorlike growth factor tumour necrosis factorαconverting enzyme neuregulin 1 betasecretase 1 malate dehydrogenase P42IP4/centaurinα1 the histone H3 dimethyl Lys4 and others and is involved in a plethora of normal brain functions Less is known about possible implications of nardilysin for brain diseases This review which includes some of our own recent findings attempts to summarize the current knowledge on possible roles of nardilysin in Alzheimer disease Down syndrome schizophrenia mood disorders alcohol abuse heroin addiction and cancer We herein show that nardilysin is a Janusfaced enzyme with regard to brain pathology being probably neuropathogenic in some diseases but neuroprotective in others

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