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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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1432-1041

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Diosmin pretreatment affects bioavailability of me

Authors: K Rajnarayana Mada S Reddy Devarakonda R Krishna
Publish Date: 2003/03/01
Volume: 58, Issue: 12, Pages: 803-807
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Abstract

After an overnight fast metronidazole two 400mg tablets was administered to 12 volunteers either alone or after a 9day pretreatment period with a oncedaily dose of diosmin 500mg tablets under direct observation Serum concentrations of metronidazole up to 48 h postdose and urinary concentrations of metronidazole and its two major metabolites up to 24 h postdose were measured using reversedphase highperformance liquid chromatographyMetronicazole plasma AUC0–∞ and Cmax were significantly higher after diosmin pretreatment by mean 27 and 24 respectively However time to reach peak concentration tmax was not affected significantly Urinary excretion of acid and hydroxy metabolites in urine was decreased significantly while excretion of unchanged metronidazole was increasedDiosmin pretreatment significantly altered the metabolism of metronidazole as demonstrated by changes in plasma pharmacokinetics as well as by urinary recovery of both parent drug and its major metabolites This may be caused by the inhibition of cytochrome P 450 enzymes

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