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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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DOI

10.1002/sim.5502

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1432-1041

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Novel strategies for the treatment of inflammatory

Authors: Atul R Chopade Wahid A Mulla
Publish Date: 2010/02/13
Volume: 66, Issue: 5, Pages: 429-444
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Abstract

There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity hyperalgesiaThe current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflammation Also the inflammatory mediators that interact with neurons to produce hyperalgesia are explored As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain with improved specificity efficacy and possibly with fewer toxic effects

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