Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Eur J Clin Pharmacol

Search In Journal Title:

Abbravation: European Journal of Clinical Pharmacology

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1007/0-387-22615-x_8

Search In DOI:

ISSN

1432-1041

Search In ISSN:
Search In Title Of Papers:

Obesity is associated with a slower response to in

Authors: Cordula Meyer zu Schwabedissen Vera Mevissen Fabian Schmitz Seth Woodruff Georg Langebartels Thomas Rau Klaus Zerres Rainer Hoffmann Jan R Ortlepp
Publish Date: 2006/07/18
Volume: 62, Issue: 9, Pages: 713-720
PDF Link

Abstract

Two hundred sixty hospital patients started on phenprocoumon were recruited for this study Body mass index BMI waist and hip circumference dietary habits comorbidity and comedication were initially assessed A 5′ exonuclease assay TaqManR was used to analyze the presence of five polymorphisms of the CYP2C9 gene in each of the study patients Study endpoints included the time necessary to achieve the international normalized ratio INR target INR 2 and the total drug amount required to attain target INR For 250 of 260 patients the subsequent required daily maintenance dose of phenprocoumon was also recordedBoth the necessary time and total dose required to attain target INR correlated significantly with BMI The leaner the patient the shorter the required time interval BMI 22 n=31 548±249 days BMI 22–25 n=70 609±240 BMI 25–30 n=113 676±361 BMI 30 n=46 850±575 p=0001 and the lower the required dosage until the therapeutic range was achieved BMI 22 n=31 238±121 mg BMI 22–25 n=70 259±114 mg BMI 25–30 n=113 296±252 BMI 30 n=46 358±197 p=0027 Overweight and waist circumference as a surrogate marker for abdominal fat were also associated significantly with these two parameters Moreover obesity was associated with a lower bodyweightadjusted maintenance dosage All CYP2C9 genotypes that were tested failed to reveal an association with individual response variability


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression
  2. Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer’s disease patients
  3. Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson’s patients
  4. Linezolid-related haematological toxicity in a peritoneal dialysis patient: the role of therapeutic drug monitoring
  5. Antibiotic prescription and prevalence rate in the outpatient paediatric population: analysis of surveys published during 2000–2005
  6. Relationship between CYP3A activity and breast cancer susceptibility in Chinese Han women
  7. Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155)
  8. Incidence and risk factors for nevirapine-associated rash
  9. Case series: paradoxical action of domperidone leads to increased vomiting
  10. Lovastatin and thalidomide have a combined effect on the rate of multiple myeloma cell apoptosis in short term cell cultures
  11. Effect of ciprofloxacin on the pharmacokinetics of ropivacaine
  12. Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients
  13. Orphan drugs, orphan diseases. The first decade of orphan drug legislation in the EU
  14. Increased frequency of CYP2C9 variant alleles and homozygous VKORC1*2B carriers in warfarin-treated patients with excessive INR response
  15. Laxative treatment elevates plasma homocysteine: a study on a population-based Swedish sample of old people
  16. Clinical pharmacology of melatonin in the treatment of tinnitus: a review
  17. Network meta-analysis of first- and second-generation protease inhibitors for chronic hepatitis C genotype 1: efficacy based on RVR and SVR 24
  18. Lack of association between SLCO1B1 polymorphism and the lipid-lowering effects of atorvastatin and simvastatin in Chinese individuals
  19. Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not
  20. Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling
  21. Off-label use of anticancer drugs in eastern Switzerland: a population-based prospective cohort study
  22. Clinical trials during pregnancy: what has been done
  23. Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore
  24. Pharmacokinetic–pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide
  25. Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects
  26. A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia
  27. Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse events
  28. Comparison of rational pharmacotherapy decision-making competence of general practitioners with intern doctors
  29. Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations
  30. Pharmacokinetic study of the interaction between itraconazole and nevirapine
  31. Mirtazapine in drug-induced excessive sweating
  32. Population pharmacokinetic analysisof lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART
  33. Diosmin pretreatment affects bioavailability of metronidazole
  34. Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios
  35. Long-term neurocognitive effects of antipsychotics in schizophrenia: a network meta-analysis
  36. Biosimilar erythropoiesis-stimulating agents and the risk of developing anti-drug antibodies—a systematic review
  37. Early discontinuation: more frequent among general practitioners with high levels of prescribing
  38. Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs
  39. Influence of bariatric surgery on the use of medication
  40. Medical speciality and pattern of medicines prescription
  41. Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes
  42. Herbal medicines – they are popular, but are they also safe?
  43. Restricted indications for the use of antibiotics in acute otitis media
  44. Motives for reporting adverse drug reactions by patient-reporters in the Netherlands
  45. The effect of acarbose on the pharmacokinetics of rosiglitazone
  46. Use of psychotropics is high among very old people
  47. Benzodiazepine use in the real world of psychiatric practice: low-dose, long-term drug taking and low rates of treatment discontinuation
  48. Prevalence of statin-drug interactions in older people: a systematic review
  49. Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
  50. Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications
  51. Factors influencing the pharmacokinetics of prophylactic posaconazole oral suspension in patients with acute myeloid leukemia or myelodysplastic syndrome
  52. Oral quinine pharmacokinetics and dietary salt intake
  53. Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis
  54. Children’s presence in research. A review of online registers
  55. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers
  56. Evidence of safety of chloral hydrate for prolonged sedation in PICU in a tertiary teaching hospital in southern Brazil
  57. Genistein alters caffeine exposure in healthy female volunteers
  58. Merck fellowships contribute to the continued growth of clinical pharmacology in Sweden
  59. Concomitant antibiotic usage does not augment the risk of inflammatory bowel disease with isotretinoin treatment for acne: a review of the Food and Drug Administration Adverse Event Reporting System
  60. Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
  61. Novel strategies for the treatment of inflammatory hyperalgesia
  62. Germ line polymorphisms as predictive markers for pre-surgical radiochemotherapy in locally advanced rectal cancer: a 5-year literature update and critical review
  63. The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing
  64. The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing
  65. Rifampicin markedly decreases the exposure to oral and intravenous tramadol
  66. Potentially inappropriate prescribing in elderly outpatients in Croatia
  67. Challenges in collecting pharmacokinetic and pharmacodynamic information in an intensive care setting: PK/PD modelling of clazosentan in patients with aneurysmal subarachnoid haemorrhage

Search Result: