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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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DOI

10.1007/s00401-007-0237-2

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1432-1041

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Pharmacokinetics of midazolam in CYP3A4 and CYP3A

Authors: Chin B Eap Thierry Buclin Elisabeth Hustert Gabriela Bleiber Kerry Powell Golay AnneCatherine Aubert Pierre Baumann Amalio Telenti Reinhold Kerb
Publish Date: 2004/04/28
Volume: 60, Issue: 4, Pages: 231-236
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Abstract

CYP3A57 CYP3A41E CYP3A42 CYP3A44 CYP3A45 CYP3A46 CYP3A48 CYP3A411 CYP3A412 CYP3A413 CYP3A417 and CYP3A418 alleles were not identified in the 21 subjects CYP3A53 CYP3A56 CYP3A41B and CYP3A41F alleles were identified in 20 1 4 and 2 subjects respectively No statistically significant differences were observed for the AUCinf values between the different genotypes after the 75µg or the 75mg dose

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