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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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DOI

10.1002/ange.19300432611

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1432-1041

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Case series paradoxical action of domperidone lea

Authors: Marco Pozzi Sandra Strazzer Federica Locatelli Sara Galbiati Francesca Formica Luciano Maestri Emilio Clementi Sonia Radice
Publish Date: 2012/06/16
Volume: 69, Issue: 2, Pages: 289-290
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Abstract

Dysphagic children who receive enteral nutrition may develop gastroparesis for which the prokinetic domperidone has become the drug of choice The most common adverse drug reactions ADRs to domperidone reported by postmarketing surveillance only comprise gastrointestinal upset and moderate induction of hyperprolactinemia 1 We now report on domperidone inducing severe vomiting in ten paediatric inpatients with severe acquired brain injury hospitalized in a neurorehabilitation unit These patients shared as pathological features spastic tetraparesis minimal consciousness and inability to assume solids or liquids orally none of them having gastric outlet obstruction Pharmacological therapy comprised baclofen diazepam valproate omeprazole and antibiotics when needed To favour gastric emptying therapeutic doses of domperidone were administered 15 to 20 minutes before meals four times a day

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