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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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1432-1041

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Psychological and physiological effects of bupropi

Authors: Hugues Chevassus Anne Farret JeanPierre Gagnol ClaireAnne Ponçon Françoise Costa Clarisse Roux Florence Galtier Pierre Petit
Publish Date: 2012/10/09
Volume: 69, Issue: 4, Pages: 779-787
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Abstract

Twelve male volunteers completed this randomized doubleblind placebo controlled crossover study Bupropion and methylphenidate were administered separately for initial halfdose 6day periods 150 and 10 mg respectively followed by fulldose 8day periods 300 and 20 mg respectively Outcomes were subjective feelings cognitive performances autonomic and physiological parametersData are expressed as meanSEM After repeated administration bupropion like methylphenidate decreased astheniafatigue 4432 and 4237 respectively vs 5341 for placebo p = 0034 despite an impairment of sleep onset 43332 and 19376 respectively vs +75369 p = 0016 Both drugs increased resting diastolic blood pressure 679123 and 657098 respectively vs 625142 mm Hg p = 0001 body temperature 365012 and 365014 vs 363010 °C p = 0037 and decreased body weight 07023 and 06022 respectively vs +02027 kg p = 0038 No significant change could be observed on cognitive functions appetite and energy consumptionThis study was successfully carried out thanks to the expert scientific medical pharmaceutical and logistic assistance of JL Allaz AM Barbanel F Barnay R Blanc B BoriesAzeau A Cadène F Collado P Dumas J Foppolo I Gabillaud A Massebiau P Rambourg D Robert and I RochTorreilles

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