Authors: Jacqueline Kohut Martinbiancho Paulo Roberto Antonacci Carvalho Eliana de Andrade Trotta Ana Paula Schweiger Renata Rau Leila Beltrami Moreira
Publish Date: 2009/08/11
Volume: 65, Issue: 12, Pages: 1253-1258
Abstract
This was a cohort study including patients with prescription of chloral hydrate hospitalized in the pediatric intensive care unit PICU of a universityaffiliated general tertiary teaching hospital Data were collected from a spreadsheet for daily monitoring and clinical events registered in the patient records were analyzed to evaluate the causality of suspected adverse drug reactions ADR applying the Naranjo algorithmThree hundred fortythree patients who had been prescribed CH were studied Ages ranged from 0 to 18 years and 63 were male The most frequent cause for PICU admission was bronchiolitis 776 and 586 required mechanical ventilation In 927 of cases CH was indicated to control agitation and in 73 for procedural sedation The median time of CH use was 6 days The incidence of suspected ADR was 227 ± 23 Oxygen desaturation was the most frequent adverse event 646 followed by hypotension Specific treatment was required in 609 of the events Chloral hydrate as cause for suspected ADR was classified as probable in 39 events 355 and as possible in 70 636 and no event was classified as definite In the multivariate analysis only mechanical ventilation was predictive of ADR to CH
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