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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer Berlin Heidelberg

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DOI

10.1002/pola.26228

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1432-1041

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Clinical pharmacology of melatonin in the treatmen

Authors: Marco Miroddi Rocco Bruno Francesco Galletti Fabrizio Calapai Michele Navarra Sebastiano Gangemi Gioacchino Calapai
Publish Date: 2015/01/20
Volume: 71, Issue: 3, Pages: 263-270
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Abstract

We performed a review with the purpose to summarise analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus Due to the fact that there is no satisfactory treatment for tinnitus clinical research has explored new therapeutic approachesA search of Pubmed Medline Embase Central and Google Scholar was conducted to find trials published prior March 2014 on melatonin in the treatment of tinnitus Design of the studies randomization allocation concealment procedures and diagnostic instruments scales for tinnitus evaluation were critical evaluatedFive clinical studies have been included Three of them tested effectiveness of melatonin alone the remaining two along with sulpiride and sulodexide respectively Considered clinical trials adopted various experimental designs single arm randomised placebocontrolled and randomised placebocontrolled followed by crossover These studies were characterised by several methodological weaknesses

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