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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer Berlin Heidelberg

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DOI

10.1016/0002-9610(80)90280-9

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1432-1041

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Potentially inappropriate prescribing in elderly o

Authors: Branislava Popović Nives Radošević Quadranti Suzana Mimica Matanović Ines Diminić Lisica Aleksandar Ljubotina Dubravka Pezelj Duliba Vera VlahovićPalčevski
Publish Date: 2014/03/21
Volume: 70, Issue: 6, Pages: 737-744
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Abstract

The purpose of this study was to determine the prevalence of inappropriate prescribing to the elderly and to identify possible genderrelated differences in prescribing certain potentially inappropriate medications PIMs to outpatients by using large administrative prescription databaseMedications prescribed for elderly outpatients ≥ 65 years in PrimorskoGoranska County Croatia who received five or more different drugs simultaneously in 2010 were analyzed The prevalence of potentially inappropriate drugs prescribed to the elderly was assessed using the new comprehensive protocol developed by authors Mimica Matanović and VlahovićPalčevskiA total of 624  of patients received at least one medication with unfavorable benefit/risk ratio in the elderly Female patients were given inappropriate medications in a significantly higher percentage than men 693  vs 505  p  0001 The average number of prescriptions for PIMs that should have been avoided with certain diseases or conditions was 088 per patient in the survey The most common drug combination potentially leading to serious drug–drug interactions DDIs included an angiotensinconverting enzyme ACE inhibitor and a potassium supplementOur study has shown that every tenth medication prescribed to a patient  65 years and receiving five or more drugs was potentially inappropriate Elderly women were prescribed PIMs more often than men Drugs of concern in female patients were benzodiazepines antidepressants and nonsteroidal antiinflammatory drugs NSAIDs In male patients there was a significantly higher proportion of possible interactions with warfarin theophylline and medications affecting the cardiovascular system such as ACE inhibitors and amiodarone

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