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Title of Journal: Eur J Clin Pharmacol

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Abbravation: European Journal of Clinical Pharmacology

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Springer-Verlag

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DOI

10.1007/bf03176080

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1432-1041

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Clinical trials during pregnancy what has been do

Authors: Viviana Domínguez Nuria Ramos Abiguei Torrents David García Xavier Carné
Publish Date: 2011/11/11
Volume: 68, Issue: 5, Pages: 455-458
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Abstract

Of 1264 retrieved publications 762 60 were excluded leaving 502 for analysis 53 were preventive studies in maternal or fetal conditions 47 were therapeutic trials mostly focused on acute obstetric diseases 66 were assigned a pharmacological intervention The studied drugs were 16 for labour induction and 15 for abortive procedures followed by multivitamins and micronutrients labour analgesia and anesthesia antibiotics tocolytics and antimalarial drugs The main objectives of the studies were focused on efficacy 54 and efficacy and safety 26 81 of the studies were controlled randomized and paralleldesign trials 19 were blindedClinical trials in pregnant women are mainly conducted with an efficacy objective regarding maternal–fetal prevention and in obstetric diseases to study labor induction and abortive measures This is in line with the type of intervention and drugs involved

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