Authors: M Ferrari C Comi F Marino L Magistrelli F De Marchi R Cantello G Riboldazzi G Bono M Cosentino
Publish Date: 2016/08/06
Volume: 72, Issue: 11, Pages: 1335-1341
Abstract
Visual hallucinations VHs are frequent nonmotor complication of Parkinson’s disease PD associated to a negative prognosis Previous studies showed an association between dopamine receptor DR gene DR variants and psychosis in Alzheimer’s disease addictions schizophrenia and bipolar disorder However there are only a few studies on DR variants and VHs in PD which did not provide conclusive resultsA casecontrol study of 84 PD subjects 42 with and 42 without VHsthat were matched for age gender disease duration and dopaminergic medication was conducted Polymerase chain reaction for SNPs in both D1like DRD1A48G rs4532 and C62T rs686 DRD5T798C rs6283 and D2like DR DRD2G2137A rs1800497 and C957T rs6277 DRD3G25A rs6280 and G712C rs1800828 DRD4C616G rs747302 and nR VNTR 48bp analyzed genomic DNAPatients carrying allele T at DRD1C62T had an increased risk of VHs expressed as OR 95 CI p value of 107 29–40 p = 00001 Moreover patients with DRD148 GG and 62TT genotype displayed shorter time to VHs whereas a longer time to VHs was found in subjects carrying the DRD4 CG allelesPD patients with VHs display higher frequency of DR SNPs associated with increased D1like activity and decreased D2like activity Our data are in line with associations reported in other neurodegenerative and psychiatric conditions Results likely provide valuable information for personalizing pharmacological therapy in PD patients
Keywords: