Authors: Paul Newton Andrew Simpson Sompon Wanwimolruk Pius Maliakal Leopoldo Villegas Daniel Kuypers Nicholas J White
Publish Date: 2014/02/07
Volume: 57, Issue: 2, Pages: 111-113
Abstract
Objectives The objective was to determine whether or not dietary salt intake affects the relative bioavailability of oral quinine Salt intake has been shown to alter quinidine bioavailability Methods The pharmacokinetic properties of oral quinine sulphate 600 mg salt were investigated in seven healthy Caucasian volunteers in a randomised crossover study on low and highsalt diets Plasma quinine concentrations were measured by highperformance liquid chromatography HPLC and the 24h urinary sodium excretion was assayed Results Although the 24h urine sodium excretion was significantly higher when the volunteers were on a highsalt diet there were no significant differences in quinine AUC0– ∞ t max and C max after the two diets The median range quinine elimination halflife was significantly shorter after a highsalt diet 85 43–102 h than after a lowsalt diet 100 76–148 h P=004 Conclusion Dietary salt does not affect the relative oral bioavailability of quinine sulphate
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