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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer-Verlag

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DOI

10.1016/0277-9536(94)00149-n

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1432-0878

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Changes in mammary fat pad composition and lipolyt

Authors: Esperanza Pujol Ana M Proenza Pilar Roca Isabel Lladó
Publish Date: 2005/11/22
Volume: 323, Issue: 3, Pages: 505-511
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Abstract

Changes in rat mammary fat pad during pregnancy were assessed by studying differences in the morphology and composition of the pad and in the levels of proteins involved in the accumulation and mobilization of fat stores During pregnancy the mammary fat pad weight had increased 18fold by day 20 as compared with control rats DNA content had increased twofold by day 13 and remained stable until day 20 Protein content showed a twofold increase on day 20 compared with control rats As pregnancy advanced both the percentage of mammary gland cells with respect to the whole mammary fat pad and the size of the adipocytes increased The specific content of the different elements of the lipolytic pathway viz α2Aadrenergic receptor AR β3AR cAMPdependent protein kinase and hormonesensitive lipase HSL underwent a decrease as pregnancy progressed although adenylate cyclase increased greatly The lipoprotein lipase LPL content per gram of tissue increased with pregnancy and the HSLtoLPL ratio reflected a continuous increase in the triglyceride storage throughout pregnancy Thus the mammary fat pad undergoes extensive morphological compositional and metabolic transformation during pregnancy attributable to the development of the mammary gland The various elements of the lipolytic pathway and LPL undergo major changes during the development of the mammary gland focused towards the increase of fat stores and allowing the accumulation of lipid droplets in the epithelial mammary cells and an increase in adipocyte sizeThis investigation was supported by the Fondo de Investigaciones Sanitarias PI021339 of the Spanish Government and by the Conselleria dInnovació i Energia de la Comunitat Autònoma de les Illes Balears PRDIB–2002GC4–24 EP was supported by a grant from the Spanish GovernmentThe authors are grateful to Dr J Oliver for his help with the preparation of the histological samples and for his useful advice regarding the measurement of the morphometric parameters We also thank Ms M Pocoví for her technical assistance on the preparation of the histological sections

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