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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer-Verlag

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DOI

10.1016/0957-4174(96)00013-9

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1432-0878

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Tenogenic differentiation of equine adiposetissue

Authors: Oksana Raabe K Shell D Fietz C Freitag A Ohrndorf H J Christ S Wenisch S Arnhold
Publish Date: 2013/02/22
Volume: 352, Issue: 3, Pages: 509-521
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Abstract

Mesenchymal stem cells have become extremely interesting for regenerative medicine and tissue engineering in the horse Stem cell therapy has been proven to be a powerful and successful instrument in particular for the healing of tendon lesions We predifferentiated equine adiposetissuederived stem cells ASCs in a collagen I gel scaffold by applying tensile strain growth differentiation factors GDFs and various oxygen tensions in order to determine the optimal conditions for in vitro differentiation toward the tenogenic lineage We compared the influence of 3 versus 21 oxygen tension the use of GDF 5 GDF 6 and GDF 7 and the application of uniaxial tensile strain versus no mechanical stimulation on differentiation results as evaluated by cell morphology and by the expression of the tendonrelevant genes collagen I collagen III cartilage oligomeric matrix protein and scleraxis The best results were obtained with an oxygen tension of 21 tensile stimulation and supplementation with GDF 5 or GDF 7 This approach raises the hope that the in vivo application of predifferentiated stem cells will improve healing and recovery time in comparison with treatment involving undifferentiated stem cells

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