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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer-Verlag

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DOI

10.1007/s12013-014-9900-0

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1432-0878

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Stromal cells cultured from omentum express plurip

Authors: Ashok K Singh Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Jose A L Arruda George Dunea
Publish Date: 2008/01/15
Volume: 332, Issue: 1, Pages: 81-88
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Abstract

When rat omentum becomes activated by intraperitoneal injection of inert polydextran particles these particles are rapidly surrounded by cells that express markers of adult stem cells SDF–1α CXCR4 WT–1 and of embryonic pluripotent cells Oct–4 Nanog SSEA–1 We have cultured such cells because they may offer a convenient source of adult stem cells and have found that they retain stem cell markers and produce high levels of vascular endothelial growth factor for up to ten passages After systemic or local injection of these cultured cells into rats with acute injury of various organs the cells specifically engraft at the injured sites Thus our experiments show that omental stromal cells can be cultured from activated omentum and that these cells exhibit stem cell properties enabling them to be used for repair and possibly for the regeneration of damaged tissues

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