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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer Berlin Heidelberg

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DOI

10.1002/chin.201248046

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ISSN

1432-0878

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BMP2 induces chondrogenic differentiation osteoge

Authors: Nian Zhou Qi Li Xin Lin Ning Hu JunYi Liao LiangBo Lin Chen Zhao ZhenMing Hu Xi Liang Wei Xu Hong Chen Wei Huang
Publish Date: 2016/04/15
Volume: 366, Issue: 1, Pages: 101-111
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Abstract

Bone morphogenetic protein 2 BMP2 a member of the transforming growth factorβ TGFβ superfamily is one of the main chondrogenic growth factors involved in cartilage regeneration BMP2 is known to induce chondrogenic differentiation in various types of stem cells in vitro However BMP2 also induces osteogenic differentiation and endochondral ossification in mesenchymal stem cells MSCs Although information regarding BMP2induced chondrogenic and osteogenic differentiation within the same system might be essential for cartilage tissue engineering few studies concerning these issues have been conducted In this study BMP2 was identified as a regulator of chondrogenic differentiation osteogenic differentiation and endochondral bone formation within the same system BMP2 was used to regulate chondrogenic and osteogenic differentiation in stem cells within the same culture system in vitro and in vivo Any changes in the differentiation markers were assessed BMP2 was found to induce chondrogenesis and osteogenesis in vitro via the expression of Sox9 Runx2 and its downstream markers According to the results of the subcutaneous stem cell implantation studies BMP2 not only induced cartilage formation but also promoted endochondral ossification during ectopic bone/cartilage formation In fetal limb cultures BMP2 promoted chondrocyte hypertrophy and endochondral ossification Our data reveal that BMP2 can spontaneously induce chondrogenic differentiation osteogenic differentiation and endochondral bone formation within the same system Thus BMP2 can be used in cartilage tissue engineering to regulate cartilage formation but has to be properly regulated for cartilage tissue engineering in order to retain the cartilage phenotypeWe acknowledge the service provided by the Chongqing Key Laboratory of Ophthalmology and the Department of Clinical Hematology at the Third Military Medical University We thank TC He of the Molecular Oncology Laboratory in the Department of Orthopedic Surgery at the University of Chicago for his donation of adenoviruses AdBMP2 AdGFP

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