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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Publisher

Springer Berlin Heidelberg

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DOI

10.1016/0090-6980(74)90067-7

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ISSN

1432-0878

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Developmental regulations of Perp in mice molar mo

Authors: Sanjiv Neupane WernJoo Sohn Girdhari Rijal YeJi Lee Sanggyu Lee Hitoshi Yamamoto ChangHyeon An SungWon Cho Youngkyun Lee HongIn Shin TaeYub Kwon JaeYoung Kim
Publish Date: 2014/05/28
Volume: 358, Issue: 1, Pages: 109-121
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Abstract

Teraspanin transmembrane protein Perp P53 apoptosis effector related to PMP22 which is found in the plasma membrane as a component of the desmosome is reported to be involved in the morphogenesis of the epithelium and the enamel formation of the incisor However its expression pattern and signaling regulation during molar development have not been elucidated in detail We have examined the precise expression patterns of Perp in developing lower molars and employed the knockdown of Perp by antisense oligodeoxynucleotide treatment during in vitro organ cultivation at embryonic day 13 to define the precise developmental function of Perp Perp was expressed mainly in the dental lamina and stellate reticulum regions at the bud and cap stages After Perp knockdown the tooth germ showed disruption of the dental lamina and stellate reticulum with altered apoptosis and proliferation The changed expression levels of related signaling molecules from the enamel knot and desmosome were evaluated by realtime quantitative polymerase chain reaction A renal capsule transplantation method was employed to examine the effects of Perp knockdown on molar crown development Ultrastructural observations revealed that enamel was deposited more densely in an irregular pattern in the cusp region and that dentin was hypomineralized after Perp knockdown at the cap stage Thus Perp might play important roles in the formation and integration of stellate reticulum dental lamina structure and enamel formation through signaling interactions with the enamel knot and desmosomerelated signaling molecules at the cap stage of lower molar developmentImmunolocalization of Perp At E165 Perp is localized in the DL SR and SI a Higher magnifications of images showing Perp localization in DL b SR c and SI d Similar localization pattern of Perp is observed in the OE DL SR and SI except the AB at PN2 and PN6 el OE Oral Epithelium DL Dental Lamina SR Stellate Reticulum SI Stratum Intermedium AB Ameloblast Scale bars 100 μm a e i 50 μm bc fg jk 10 μm d h l GIF 384 kbEDXanalysis EDXA of kidney capsule calcified control ac and ASODN df teeth The EDXA mapping images bc ef for calcium and phosphorus distribution are based on SEM micrographs a d The table shows the calcium and phosphorus distribution in the control and ASODN teeth Ca Calcium P Phosphorus GIF 241 kb

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