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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer Berlin Heidelberg

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DOI

10.1007/bf01324904

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ISSN

1432-0878

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The chemical coding of 5hydroxytryptamine contain

Authors: Yohan Reynaud Josiane Fakhry Linda Fothergill Brid Callaghan Mitchell Ringuet Billie Hunne David M Bravo John B Furness
Publish Date: 2016/01/23
Volume: 364, Issue: 3, Pages: 489-497
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Abstract

The majority of 5HT serotonin in the body is contained in enteroendocrine cells of the gastrointestinal mucosa From the time of their discovery over 80 years ago the 5HTcontaining cells have been regarded as a class of cell that is distinct from enteroendocrine cells that contain peptide hormones However recent studies have cast doubt on the concept of there being distinct classes of enteroendocrine cells each containing a single hormone or occasionally more than one hormone Instead data are rapidly accumulating that there are complex patterns of colocalisation of hormones that identify multiple subclasses of enteroendocrine cells In the present work multiple labelling immunohistochemistry is used to investigate patterns of colocalisation of 5HT with enteric peptide hormones Over 95  of 5HT cells in the duodenum also contained cholecystokinin and about 40  of them also contained secretin In the jejunum about 75  of 5HT cells contained cholecystokinin but not secretin and 25  contained 5HT plus both cholecystokinin and secretin Small proportions of 5HT cells contained gastrin or somatostatin in the stomach PYY or GLP1 in the small intestine and GLP1 or somatostatin in the large intestine Rare or very rare 5HT cells contained ghrelin stomach neurotensin small and large intestines somatostatin small intestine and PYY in the large intestine It is concluded that 5HTcontaining enteroendocrine cells are heterogeneous in their chemical coding and by implication in their functions


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  62. Acknowledgement to reviewers
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