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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer-Verlag

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DOI

10.1007/s11075-010-9425-6

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1432-0878

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Agrin becomes concentrated at neuroeffector juncti

Authors: J Gingras J Spicer M Altares Q Zhu G A Kuchel M Ferns
Publish Date: 2005/02/16
Volume: 320, Issue: 1, Pages: 115-125
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Abstract

The formation of somatic neuromuscular junctions in skeletal muscle is regulated by an extracellular matrix protein called agrin Here we have examined the expression and localization of agrin during development of the rodent urinary bladder as a first step to examining its possible role at autonomic neuroeffector junctions in smooth muscle We have found that agrin is expressed on the surface of developing smooth muscle cells and in the basement membrane underlying the urothelium More importantly agrin is progressively concentrated at parasympathetic varicosities during postnatal development and is present at virtually all junctions in mature muscle Reverse transcription/polymerase chain reaction analysis has shown that pelvic ganglion neurons that innervate the bladder express LN/z8 agrin whereas bladder smooth muscle expresses LN/z− agrin Together these results demonstrate that nerve and/or muscle agrin becomes localized at cholinergic parasympathetic varicosities in smooth muscle where it could play a role in the maturation of the neuroeffector junction

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