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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer-Verlag

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DOI

10.1007/BF01538242

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1432-0878

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Differential expression of the bone and the liver

Authors: Isabelle BrunHeath Myriam Ermonval Elodie Chabrol Jinsong Xiao Miklós Palkovits Ruth Lyck Florence Miller PierreOlivier Couraud Etienne Mornet Caroline Fonta
Publish Date: 2010/12/31
Volume: 343, Issue: 3, Pages: 521-536
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Abstract

The enzyme tissue nonspecific alkaline phosphatase TNAP belongs to the ectophosphatase family It is present in large amounts in bone in which it plays a role in mineralization but little is known about its function in other tissues Arguments are accumulating for its involvement in the brain in particular in view of the neurological symptoms accompanying human TNAP deficiencies We have previously shown by histochemistry alkaline phosphatase AP activity in monkey brain vessels and parenchyma in which AP exhibits specific patterns Here we clearly attribute this activity to TNAP expression rather than to other APs in primates human and marmoset and in rodents rat and mouse We have not found any brainspecific transcripts but our data demonstrate that neuronal and endothelial cells exclusively express the bone TNAP transcript in all species tested except in mouse neurons in which liver TNAP transcripts have also been detected Moreover we highlight the developmental regulation of TNAP expression this also acts during neuronal differentiation Our study should help to characterize the regulation of the expression of this ectophosphatase in various cell types of the central nervous systemWe thank Dr Lászlo Négyessi Semmelweiss University Budapest Hungary and Gabor G Kovacs former National Institute of Psychiatry and Neurology Budapest Hungary for support and advice and for providing human samples We are grateful to Prof Jean Sautet for his valuable expertise in embryonic anatomy We thank Luc Renaud for the histology work We acknowledge Prof Odile Kellermann and Prof JeanMarie Launay for material derived from the 1C11 neuronal model We are also grateful to Simon Heath for careful reading of the manuscript

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