Authors: Silvia Fischer Hector A CabreraFuentes Thomas Noll Klaus T Preissner
Publish Date: 2014/03/14
Volume: 355, Issue: 3, Pages: 635-645
Abstract
Different types of high and low molecular weight extracellular RNA eRNA are liberated from cells upon conditions of tissue damage or vascular diseases and have been demonstrated in vivo and in vitro to influence the integrity and barrier function of the vascular endothelium Among the types of self eRNA studied in this respect ribosomal RNA appears to engage cytokines to promote hyperpermeability while counteracting RNase1 serves as a potent vesselprotective factor Different microRNAs may change the expression program of endothelial cells with consequences for cellular contacts and stability Nonself viral RNAs are recognized by Tolllike receptors that transmit intracellular inflammation signals to disturb the vascular barrier function largely in connection with infectious diseases Although derived from the same nucleotide building blocks the various forms of eRNA exhibit a multitude of molecular interactions with the endothelium that may drastically change its phenotypical characteristics The impact of eRNA on vascular integrity in health and disease is summarized in this concise reviewThe authors acknowledge the experimental work of Dr Mohammad Aslam Dept Physiology JLU Giessen The work of the authors cited in this article was supported by the Deutsche Forschungsgemeinschaft DFG Bonn Germany Excellence Cluster “Cardiopulmonary System” ECCPS grants FI 543/21 and IRTG1566
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