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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Springer Berlin Heidelberg

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DOI

10.1016/0952-8180(95)00197-2

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ISSN

1432-0878

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Characterization of miRNA processing machinery in

Authors: Rute Silva Moura Patrícia VazCunha Carla SilvaGonçalves Jorge CorreiaPinto
Publish Date: 2015/07/23
Volume: 362, Issue: 3, Pages: 569-575
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Abstract

Lung development is a very complex process that relies on the interaction of several signaling pathways that are controlled by precise regulatory mechanisms Recently microRNAs miRNAs small noncoding regulatory RNAs have emerged as new players involved in gene expression regulation controlling several biological processes such as cellular differentiation apoptosis and organogenesis in both developmental and disease processes Failure to correctly express some specific miRNAs or a component of their biosynthetic machinery during embryonic development is disastrous resulting in severe abnormalities Several miRNAs have already been identified as modulators of lung development Regarding the spatial distribution of the processing machinery of miRNAs only two of its members dicer1 and argonaute have been characterized The present work characterizes the expression pattern of drosha dgcr8 exportin5 and dicer1 in early stages of the embryonic chick lung by whole mount in situ hybridization and crosssection analysis Overall these genes are coexpressed in dorsal and distal mesenchyme and also in growing epithelial regions The expression pattern of miRNA processing machinery supports the previously recognized regulatory role of this mechanism in epithelial and mesenchymal morphogenesis

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