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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Kluwer Academic Publishers

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DOI

10.1016/0008-8749(86)90240-6

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ISSN

1573-675X

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Activation of mitogenactivated protein kinases is

Authors: TC Ho YC Yang HC Cheng AC Wu SL Chen HK Chen YP Tsao
Publish Date: 2006/08/21
Volume: 11, Issue: 11, Pages: 1899-1908
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Abstract

Retinal pigment epithelial RPE cells are constantly exposed to oxidative injury while clearing byproducts of photoreceptor turnover a circumstance thought to be responsible for degenerative retinal diseases The mechanisms of hydrogen peroxide H2O2induced apoptosis in RPE cells are not fully understood We studied signal transduction mechanisms of H2O2induced apoptosis in the human RPE cell line ARPE19 Activation of two stress kinases JNK and p38 occurs during H2O2 stimulation and H2O2mediated cell death was significantly reduced by their specific inhibition Exposure to a lethal dose of H2O2 elicited Bax translocation to the mitochondria and release of apoptosisinducing factor AIF from the mitochondria both of which were abolished by either JNK or p38specific inhibitors Both H2O2induced cell death and JNK/p38 phosphorylation were partially inhibited by C difficile toxin B inhibitor of Rho Rac and cdc42 Use of pulldown assays revealed that the small GTPase activated by H2O2 is Rac1 This study is the first to demonstrate that H2O2 induces a Rac1/JNK1/p38 signaling cascade and that JNK and p38 activation is important for H2O2induced apoptosis as well as AIF/Bax translocation of RPE cells

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  1. Annexin II receptor induces apoptosis independent of Annexin II
  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. APLP1 promotes dFoxO-dependent cell death in Drosophila
  6. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  7. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  8. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  9. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  10. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  11. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  12. Synchronized turbo apoptosis induced by cold-shock
  13. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  14. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  15. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  16. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  17. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  18. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  19. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  20. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  21. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  25. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  28. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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