Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Apoptosis

Search In Journal Title:

Abbravation: Apoptosis

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1016/0090-8258(80)90140-7

Search In DOI:

ISSN

1573-675X

Search In ISSN:
Search In Title Of Papers:

Cellular responses to endoplasmic reticulum stress

Authors: Vanya I Rasheva Pedro M Domingos
Publish Date: 2009/04/10
Volume: 14, Issue: 8, Pages: 996-1007
PDF Link

Abstract

The endoplasmic reticulum ER is the cell organelle where secretory and membrane proteins are synthesized and folded Correctly folded proteins exit the ER and are transported to the Golgi and other destinations within the cell but proteins that fail to fold properly—misfolded proteins—are retained in the ER and their accumulation may constitute a form of stress to the cell—ER stress Several signaling pathways collectively known as unfolded protein response UPR have evolved to detect the accumulation of misfolded proteins in the ER and activate a cellular response that attempts to maintain homeostasis and a normal flux of proteins in the ER In certain severe situations of ER stress however the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis Most research on the UPR used yeast or mammalian model systems and only recently Drosophila has emerged as a system to study the molecular and cellular mechanisms of the UPR Here we review recent advances in Drosophila UPR research in the broad context of mammalian and yeast literature

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Annexin II receptor induces apoptosis independent of Annexin II
  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
  14. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  15. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  20. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  21. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  22. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  23. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  24. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  25. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  26. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  27. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  28. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  29. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  30. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
Search Result: