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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1016/0375-9474(83)90346-9

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ISSN

1573-675X

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Thymosin alpha 1 suppresses proliferation and indu

Authors: Yan Guo Hui Chang Jing Li Xinyuan Xu Lan Shen Zhibin Yu Wenchao Liu
Publish Date: 2015/05/23
Volume: 20, Issue: 8, Pages: 1109-1121
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Abstract

Thymosin alpha 1 Tα1 an immunoactive peptide has been shown to inhibit cell proliferation and induce apoptosis in human leukemia nonsmall cell lung cancer melanoma and other human cancers However the response and molecular mechanism of breast cancer cells exposed to Tα1 remain unclear PTEN a tumor suppressor gene is frequently mutated in a variety of human cancers In the present study we aimed to investigate the biological roles of PTEN in the growth inhibition of human breast cancer cells exposed to Tα1 Using wildtype and mutant PTENexpressing cells we found a strong correlation between PTEN status and Tα1mediated growth inhibition of breast cancer cells The growth inhibition effect was more pronounced in breast cancer cells in which Tα1 enhanced PTEN expression whereas endogenous PTEN knockdown reversed the growth inhibition effect of Tα1 in breast cancer cells Further investigation revealed that PTEN upregulation which was induced by Tα1 can inhibit the activation of the PI3K/Akt/mTOR signaling pathway leading to the growth inhibition of breast cancer cells The addition of the synergy between Tα1 and the inhibition of PI3K/Akt/mTOR activation could strongly block cell viability in PTEN downregulated breast cancer cells PTENoverexpressing cells not only upregulated Bax and cleaved caspase3/9 and PARP expression but also downregulated Bcl2 compared to the treatment with Tα1 alone Together these findings suggest that PTEN mediates Tα1induced apoptosis through the mitochondrial death cascade and inhibition of the PI3K/Akt/mTOR signaling pathway in breast cancer cells

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
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  5. APLP1 promotes dFoxO-dependent cell death in Drosophila
  6. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  7. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  8. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  9. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  10. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  11. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  12. Synchronized turbo apoptosis induced by cold-shock
  13. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  14. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  15. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  16. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  17. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  18. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  19. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  20. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  21. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
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  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
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  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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