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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1016/j.amc.2013.03.021

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ISSN

1573-675X

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Atorvastatin inhibits the apoptosis of human umbil

Authors: Ye Chang Yuan Li Ning Ye Xiaofan Guo Zhao Li Guozhe Sun Yingxian Sun
Publish Date: 2016/07/09
Volume: 21, Issue: 9, Pages: 977-996
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Abstract

This study was aimed to evaluate lysosomes–mitochondria crosssignaling in angiotensin II Ang IIinduced apoptosis of human umbilical vein endothelial cells HUVECs and whether atorvastatin played a protective role via lysosomalmitochondrial axis Apoptosis was detected by flow cytometry Hoechst 33342 and AO/EB assay The temporal relationship of lysosomal and mitochondrial permeabilization was established Activity of Cathepsin D CTSD was suppressed by pharmacological and genetic approaches Proteins production were measured by western blotting Our study showed that Ang II could induce the apoptosis of HUVECs in a dosedepended and timedepended manner Exposure to 1 μM Ang II for 24 h resulted in mitochondrial depolarization cytochrome c release and increased ROS production Lysosomal permeabilization and CTSD redistribution into the cytoplasm occurred several hours prior to mitochondrial dysfunction These effects were all suppressed by atorvastatin Either pharmacological or genetic inhibition of CTSD preserved mitochondrial function and decreased apoptosis in HUVECs Most importantly we found that the protective effect of atorvastatin was significantly greater than pharmacological or genetic inhibition of CTSD Finally overexpression of CTSD without exposure to Ang II had no effect on mitochondrial function and apoptosis Our data strongly suggested that Ang II induced apoptosis through the lysosomalmitochondrial axis in HUVECs Furthermore atorvastatin played an important role in the regulation of lysosomes and mitochondria stability resulting in an antagonistic role against Ang II on HUVECs

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
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  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  10. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  11. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  12. Synchronized turbo apoptosis induced by cold-shock
  13. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  14. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  15. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  16. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  17. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  18. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  19. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  20. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  21. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  25. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
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  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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