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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Kluwer Academic Publishers

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DOI

10.1016/j.acvd.2016.05.007

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ISSN

1573-675X

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Sulindacderived reactive oxygen species induce ap

Authors: SungKeum Seo HyungChahn Lee SangHyeok Woo HyeonOk Jin DooHyun Yoo SuJae Lee Sungkwan An TaeBoo Choe MyungJin Park SeokIl Hong InChul Park ChangHun Rhee
Publish Date: 2006/11/21
Volume: 12, Issue: 1, Pages: 195-
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Abstract

Nonsteroidal antiinflammatory drugs are well known to induce apoptosis of cancer cells independent of their ability to inhibit cyclooxygenase2 but the molecular mechanism for this effect has not yet been fully elucidated The purpose of this study was to elucidate the potential signaling components underlying sulindacinduced apoptosis in human multiple myeloma MM cells We found that sulindac induces apoptosis by promoting ROS generation accompanied by opening of mitochondrial permeability transition pores release of cytochrome c and apoptosis inducing factor from mitochondria followed by caspase activation Bcl2 cleavage and downregulation of the inhibitor of apoptosis proteins IAPs family including cIAP1/2 XIAP and survivin occurred downstream of ROS production during sulindacinduced apoptosis Forced expression of survivin and Bcl2 blocked sulindacinduced apoptosis Most importantly sulindacderived ROS activated p38 mitogenactivated protein kinase and p53 SB203580 a p38 mitogenactivated protein kinase inhibitor and RNA inhibition of p53 inhibited the sulindacinduced apoptosis Furthermore p53 Bax and Bak accumulated in mitochondria during sulindacinduced apoptosis All of these events were significantly suppressed by SB203580 Our results demonstrate a novel mechanism of sulindacinduced apoptosis in human MM cells namely accumulation of p53 Bax and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
  14. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  15. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  20. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  21. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  25. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  28. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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