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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1007/bf00307429

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ISSN

1573-675X

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Fas/FasL pathwaymediated alveolar macrophage apop

Authors: Sanqiao Yao Liying Wang Rojanasakul Zhiyuan Chen Yingjun Xu Yuping Bai Gang Chen Xiying Zhang Chunmin Zhang Yanqin Yu Fuhai Shen Juxiang Yuan Jie Chen Qincheng He
Publish Date: 2011/09/11
Volume: 16, Issue: 12, Pages: 1195-
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Abstract

In vitro and in vivo studies have demonstrated that lung cell apoptosis is associated with lung fibrosis however the relationship between apoptosis of alveolar macrophages AMs and human silicosis has not been addressed In the present study AM apoptosis was determined in wholelung lavage fluid from 48 male silicosis patients 13 male observers and 13 male healthy volunteers The relationships between apoptosis index AI and silica exposure history soluble Fas sFas/membranebound Fas mFas and caspase3/caspase8 were analyzed AI mFas and caspase3 were significantly higher in lung lavage fluids from silicosis patients than those of observers or healthy volunteers but the level of sFas demonstrated a decreasing trend AI was related to silica exposure upregulation of mFas and activation of caspase3 and 8 as well as influenced by smoking status after adjusting for confounding factors These results indicate that AM apoptosis could be used as a potential biomarker for human silicosis and the Fas/FasL pathway may regulate this process The present data from human lung lavage samples may help to understand the mechanism of silicosis and in turn lead to strategies for preventing or treating this diseaseWe would like to acknowledge the other staff from the Department of Pneumoconiosis of “Beidaihe Sanatorium for China Coal Miners” for wholelung lavage and also appreciate those who assisted us at Hebei United University and China Medical University We also would like to give thanks to BioMed Proofreading LLC for their careful copy editing The programs were supported by the Natural Science Foundation of China 30671741 Pneumoconiosis Treatment Foundation for China Coal Miners 200503 and Science and Technology Support Program of Hebei Province 09276196D

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  1. Annexin II receptor induces apoptosis independent of Annexin II
  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
  14. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  15. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  20. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  21. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  22. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  23. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  24. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  25. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  28. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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