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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1016/0022-0248(68)90049-3

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1573-675X

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Mitochondrionmediated apoptosis induced by Empha

Authors: YouHua Huang XiaoHong Huang JianFang Gui QiYa Zhang
Publish Date: 2007/06/06
Volume: 12, Issue: 9, Pages: 1569-1577
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Abstract

A fish cell line fathead minnow FHM cell was used to investigate the alteration of mitochondrial dynamics and the mechanism of apoptosis under Rana grylio virus RGV infection Microscopy observations flowcytometry analysis and molecular marker detection revealed the apoptotic fate of the RGVinfected cells Some typical apoptotic characteristics such as chromatin condensation DNA fragmentation and mitochondrial fragmentation were observed and significantly morphological changes of mitochondria including size shape internal structure and distribution were revealed The mitochondria in RGVinfected cells were aggregated around the viromatrix and the aggregation could be blocked by colchicine Moreover the Δψm collapse was induced and caspase9 and caspase3 were activated in the RGVinfected cells In addition NFκB activation and intracellular Ca2+ increase were also detected at different times after infection The data revealed the detailed dynamics of mitochondrionmediated apoptosis induced by an iridovirus and provided the first report on mitochondrial fragmentation during virusinduced apoptosis in fish cellsGrateful thanks for Ms ZhengQiu Li and XiuPing Yuan who provide great help This study was supported by grants from the National Major Basic Research Program 2004CB117403 the National 863 High Technology Research Foundation of China 2006AA09Z445 and 2006AA100309 the National Natural Science Foundation of China 30671616 and U0631008 and the Project of Chinese Academy of Sciences KSCX2YWN021

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
  14. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  15. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  20. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  21. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  22. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  23. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  24. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  25. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  28. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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