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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1006/geno.1999.6028

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1573-675X

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Overexpression of CREB protein protects from tunic

Authors: András Balogh Mária Németh Ibolya Koloszár Lajos Markó Lukasz Przybyl Kazushi Jinno Csilla Szigeti Marija Heffer Matthias Gebhardt József Szeberényi Dominik N Müller György Sétáló Marianna Pap
Publish Date: 2014/04/11
Volume: 19, Issue: 7, Pages: 1080-1098
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Abstract

Endoplasmic reticulum ER stress plays an essential role in unfolded protein response induced apoptosis contributing to several pathological conditions Glycogen synthase kinase3β GSK3β plays a central role in several apoptotic signaling including ER stress as the active form of GSK3β induces apoptosis The phosphorylation of cAMP responsive element CRE binding protein CREB Ser133 S133 residue is the endpoint of various signaling pathways like growth factor signaling while the Ser129 S129 residue is phosphorylated by GSK3β The significance of the ubiquitously expressed transcription factor CREB is demonstrated in prolonged tunicamycin TMinduced ER stress in this study In the experiments wildtype wt CREB S129Ala S133Ala or S129Ala–S133Ala mutant CREB expressing PC12 rat pheochromocytoma cell lines showed increased survival under TMevoked prolonged ER stress compared to wtPC12 cells After TM treatment ER stress was activated in all PC12 cell types Lithium and SB216763 the selective wellknown inhibitors of GSK3β decreased TMinduced apoptosis and promoted cell survival The proapoptotic BH3only Bcl2 family member Bcl2interacting mediator of cell death Bim level was decreased in the different CREB overexpressing PC12 cells as a result of TM treatment CREB overexpression also inhibited the sequestration of Bim protein from tubulin molecules as it was demonstrated in wtPC12 cells Transient expression of wtCREB diminished TMinduced apoptosis in wtPC12 Rat1 and primary rat vascular smooth muscle cells These findings demonstrate a novel role of CREB in different cell types as a potent protector against ER stressThis work was supported by Grants from the Hungarian National Research Fund to József Szeberényi OTKA T037528 and from Pécs University to Marianna Pap PTE AOK KA 3403913/2009 The purchase of the Olympus FV1000 laser scanning confocal system was supported by Grant GVOP3212004040172/30 to Pécs University The authors would like to thank Gabriele N’diaye for the outstanding technical assistance

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
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  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
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  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  20. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
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  22. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  23. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
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  29. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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