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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1016/0045-7949(95)00112-t

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ISSN

1573-675X

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Insulin inhibits myocardial ischemiainduced apopt

Authors: Wenjuan Xing Wenjun Yan Feng Fu Yulan Jin Lele Ji Wenchong Liu Li Wang Anlin Lv Yunyan Duan Jun Zhang Haifeng Zhang Feng Gao
Publish Date: 2009/07/10
Volume: 14, Issue: 9, Pages: 1050-1060
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Abstract

Insulin has been shown to possess significant antiapoptotic effect in myocardial ischemia/reperfusion MI/R However the contribution by this protection of insulin to the prolonged cardiac function in rats subjected to ischemia remains unclear The present study attempted to test whether early insulin treatment influences adverse prolonged postischemic cardiac structural and functional changes Adult male rats were subjected to left anterior descending coronary artery occlusion and were randomized to receive one of the following treatments saline 4 ml/kg/h iv injection beginning 10 min before the ischemia and continuing for 2 h insulin 60 U/l iv injection following the same routine and hypodermic injection of insulin 05 U/ml 1 ml/kg/d for 3 days after the ischemia surgery or insulin plus wortmannin 15 μg/kg iv injection 15 min before each insulin administration Treatment with insulin significantly reduced infarct size decreased plasma creatine kinase and lactate dehydrogenase activities decreased apoptosis index and caspase3 activity all P  001 vs saline and improved cardiac function 24 h after ischemia Importantly at the end of 4 weeks after the ischemia surgery MI rats receiving insulin treatment showed smaller left ventricle LV cavity and thicker systolic interventricular septum and increased cardiac ejection fraction and LV fractional shortening all P  005 vs saline Inhibition of insulin signaling with wortmannin not only blocked insulin’s antiapoptotic effect but also almost completely abolished effects of insulin on cardiac structure and function These data indicate that inhibition of apoptosis by early insulin treatment alleviates chronic adverse changes in postischemic cardiac structure and functionThis study was supported by the National Science Fund for Outstanding Young Investigators No30625033 National Basic Research Program of China No2007CB512106 and grants from the National Natural Science Foundation of China Nos 30800376 30800447

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  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
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  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. APLP1 promotes dFoxO-dependent cell death in Drosophila
  7. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  8. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  9. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  10. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  11. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  12. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  13. Synchronized turbo apoptosis induced by cold-shock
  14. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  15. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  16. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  17. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  18. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  19. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  20. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  21. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
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  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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