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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1016/0378-3758(92)90141-e

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1573-675X

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Novel antiapoptotic effect of TBX15 overexpressio

Authors: Jéssica Arribas Esteban Giménez Ricard Marcos Antonia Velázquez
Publish Date: 2015/07/28
Volume: 20, Issue: 10, Pages: 1338-1346
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Abstract

Tbox genes regulate development processes some of these genes having also a role in cell proliferation and survival TBX15 is a Tbox transcription factor that recently has been proposed as a marker in prostate cancer but its function in carcinogenesis is unknown Here the role of TBX15 in carcinogenesis was investigated using thyroid cancer cell lines First using western blot analysis we show that the expression of TBX15 was altered in thyroid cancer cells lines with respect to normal thyroid cells Transfection of thyroid cancer cells with TBX15 in the presence or absence of camptothecin as a cytotoxic agent proved non effect of TBX15 in cell viability but it increased cell proliferation after 48 h of transfection P  001 Consistently apoptosis was reduced in TBX15 transfected cells P  001 which also showed a decrease of the proapoptotic Bax regulator and an increase of the antiapoptotic Bcl2 and BclXL regulators Additionally siRNA shutdown of constitutive TBX15 increased apoptosis TBX15 transfection did not alter colony formation and cell migration Taken together these results indicate for the first time an antiapoptotic role of TBX15 in cancer cells suggesting a contribution of TBX15 in carcinogenesis and the potential therapeutic target of TBX15We thank Prof Dr Andreas Kispert Institut für Molekularbiologie Medizinische Hochschule Hannover Hannover Germany for providing the plasmid pcDNA31TBX15 We also thank Dr Enrique Fernández and Tatiana Cajuso for their helpful contributions to this work and Cristian Valiente for his technical support J Arribas and E Giménez were supported by a predoctoral fellowship PIF from the Universitat Autònoma de Barcelona This research was supported by Grand support Spanish Ministry of Education and Science Project SAF20076338 and the Generalitat de Catalunya CIRIT 2009SGR725

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