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Title of Journal: Apoptosis

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Abbravation: Apoptosis

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Springer US

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DOI

10.1007/bf01701313

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ISSN

1573-675X

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APLP1 promotes dFoxOdependent cell death in Emph

Authors: Xingjun Wang Yeqing Ma Yu Zhao Yujun Chen Yujia Hu Changyan Chen Yingyao Shao Lei Xue
Publish Date: 2015/03/05
Volume: 20, Issue: 6, Pages: 778-786
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Abstract

The amyloid precursor like protein1 APLP1 belongs to the amyloid precursor protein family that also includes the amyloid precursor protein APP and the amyloid precursor like protein2 APLP2 Though the three proteins share similar structures and undergo the same cleavage processing by α β and γsecretases APLP1 shows divergent subcellular localization from that of APP and APLP2 and thus may perform distinct roles in vivo While extensive studies have been focused on APP which is implicated in the pathogenesis of Alzheimer’s disease the functions of APLP1 remain largely elusive Here we report that the expression of APLP1 in Drosophila induces cell death and produces developmental defects in wing and thorax This function of APLP1 depends on the transcription factor dFoxO as the depletion of dFoxO abrogates APLP1induced cell death and adult defects Consistently APLP1 upregulates the transcription of dFoxO target hid and reapertwo well known proapoptotic genes Thus the present study provides the first in vivo evidence that APLP1 is able to induce cell death and that FoxO is a crucial downstream mediator of APLP1’s activityWe thank Dr Merders Dr Partridge and the Bloomington Drosophila Stock Center for fly stocks This work is supported by the National Basic Research Program of China 973 Program 2010CB944901 2011CB943903 National Natural Science Foundation of China 31071294 31171413 31371490 the Specialized Research Fund for the Doctoral Program of Higher Education of China 20120072110023 and Shanghai Committee of Science and Technology 09DZ2260100 14JC1406000

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  1. Annexin II receptor induces apoptosis independent of Annexin II
  2. p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
  3. Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly
  4. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
  5. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells
  6. Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways
  7. Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid
  8. Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis
  9. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
  10. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
  11. Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1α independent mechanisms
  12. Synchronized turbo apoptosis induced by cold-shock
  13. Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
  14. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia
  15. Shogaols at proapoptotic concentrations induce G 2 /M arrest and aberrant mitotic cell death associated with tubulin aggregation
  16. Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure
  17. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
  18. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function
  19. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells
  20. Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3- O -gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
  21. Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction
  22. In vitro antiproliferative, pro-apoptotic, antimetastatic and anti-inflammatory potential of 2,4-diacteylphloroglucinol (DAPG) by Pseudomonas aeruginosa strain FP10
  23. Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents
  24. Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
  25. Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells
  26. Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
  27. Nanosecond pulsed electric fields modulate the expression of Fas/CD95 death receptor pathway regulators in U937 and Jurkat Cells
  28. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
  29. Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types
  30. Cellular responses to endoplasmic reticulum stress and apoptosis
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