Authors: D A de Luis D Pacheco R Aller M González Sagrado O Izaola M C Terroba L Cuellar R Conde T Martin J L Perez Castrillon
Publish Date: 2008/05/17
Volume: 20, Issue: 7, Pages: 895-899
Abstract
Bariatric surgery is the most effective longterm treatment for morbid obesity reducing obesityassociated comorbidities The purpose of the present study was to evaluate the UCP3 promotor 55C→T polymorphism outcomes 1 year after biliopancreatic diversion in morbidly obese patientsA sample of 40 morbidly obese patients BMI 40 kg/m2 were operated Weight fat mass blood pressure basal glucose triacylglycerols total cholesterol lowdensity lipoprotein cholesterol and highdensity lipoprotein cholesterol were measured at basal visit and at each visit The frequency of patients with diabetes mellitus hypertension and hyperlipidemia was recorded at each visitTwentyeight patients 70 had the genotype C/C wild group and 12 30 patients C/T mutant group In wild type group body mass index weight fat mass systolic blood pressure glucose total cholesterol lowdensity lipoprotein cholesterol and triacylglycerols concentrations decreased In mutant type group the same parameters improved without statistical differences with wild group Initial weight percent loss at 1 year of followup was similar in both genotypes 341 vs 286 ns
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