Authors: Séverine Ledoux Muriel Coupaye Catherine Bogard Cristine Clerici Simon Msika
Publish Date: 2010/09/03
Volume: 21, Issue: 1, Pages: 78-86
Abstract
Effectiveness of gastric bypass GBP on reduction of vascular risk factors is well established but GBP induces nutritional deficits that could reduce the cardiovascular benefit of weight loss Particularly hyperhomocysteinemia now clearly identified as a vascular risk factor has been described after GBP The aim of this study was to clarify the factors associated with increased homocysteine concentration after GBPHomocysteine concentration and multiple nutritional parameters were measured in 213 consecutive subjects One hundred and eight subjects were studied before surgery control CT 115 one to 6 years after GBP and 41 both before and 6 months after GBPHomocysteine concentration did not differ before and after GBP 91 ± 32 vs 86 ± 34 μmol/l but 94 of subjects had been supplemented with a multivitamin preparation after surgery The nutritional parameters best correlated with homocysteine concentration both before and after GBP were folate and creatinine concentrations p 00001 In contrast vitamin B12 and metabolic parameters including glucose insulin lipids and Creactive protein were not associated with homocysteine concentration After GBP homocysteine concentration was significantly lower in subjects taking a multivitamin supplementation containing a high dose of folate than those who did not 77 ± 28 vs 101 ± 39 μmol/l p 00001The authors thank Anne Mabille and Etienne Larger for their careful reading of the manuscript Thierry Dupré Service de Biochimie Hôpital Bichat Paris for biochemical assays and the staff of the nutrition unit of the Hôpital Louis Mourier for his assistance in patient’s management
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