Authors: Picard Marceau Simon Marceau Simon Biron FredericSimon Hould Stefane Lebel Odette Lescelleur Laurent Biertho John G Kral
Publish Date: 2010/09/12
Volume: 20, Issue: 12, Pages: 1609-1616
Abstract
In the last 16 years we performed open biliopancreatic diversion with duodenal switch DS in 13 adolescents aged 15–17 years who have been followed up for 2–16 years mean 106 years three with PraderWilli syndrome PWS are presented separatelyAmong the ten nonPWS children 7 girls no deaths or perioperative complications were reported mean body mass index BMI decreased from 559 ± 140 to 288 ± 37 kg/m2 excess weight loss EWL = 821 ± 105 and none have regained weight All comorbidities were cured except asthma which improved in one patient There were two reoperations one for intestinal obstruction and one for postanastomotic ulcer Glucose and lipid metabolism improved while vitamin and mineral deficiencies were mild and rare Five of the seven girls gave birth to 11 children aged 2–12 years two of whom are overweight but not severely obese Neurodevelopment is ageappropriate in all 11 individuals PWS children aged 15–16 years had postoperative respiratory and infectious complications necessitating hospitalizations of 13–22 days versus 51 ± 12 days in nonPWS Weight loss and comorbidity improvement lasted approximately 5 years providing improved quality of life for patient and family One PWS patient died from complications after reoperation for weight regain after 4 years One was reoperated after 6 years and the third is considering reoperation 14 years after primary DS
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