Authors: Belgin SüsleyiciDuman Kağan Zengin Figen Esin Kayhan Meliha Koldemir Fatma Kaya Dağıstanlı Penbe Çağatay Melek Öztürk Mustafa Taşkın
Publish Date: 2011/05/21
Volume: 21, Issue: 11, Pages: 1766-1773
Abstract
Fat mass and obesityassociated protein FTO gene expression is known to correlate with obesity Our aim was to investigate the FTO gene expression in paired omental and subcutaneous human adipose tissues from morbid and obese patients To understand the role of CD68positive macrophages in adipose tissues the correlation with adiposity parameters such as adipocyte diameter and adipocyte radius was also measured Drug and adiposity correlations were also analyzedPaired omental and subcutaneous adipose tissue were excised during elective surgery from morbidly obese n = 9 and obese n = 5 patients FTO expressions were determined by quantitative PCR Tissue sections were analyzed for their CD68 protein expressions by immunuhistochemistryOmental and subcutaneous adipose tissue FTO gene expression levels were not found to differ significantly among morbidly obese and obese study groups Serum aspartate aminotransferase e and alanine transaminase levels were found to be in negative correlation with subcutaneous fat tissue FTO expression rate Antidiabetic drug use was found to be in correlation with adiposity Both subcutaneous and omental fat cell diameters were found to have correlation with antidiabetic drug use Omental fat cell diameter was found to enlarge together with omental CD68 protein expression Subcutaneous macrophage number decreased while omental fat cell radius increased Omental macrophage number was found in correlation with subcutaneous macrophage number
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