Authors: José I BotellaCarretero José A Balsa Clotilde Vázquez Roberto Peromingo Manuela DíazEnriquez Héctor F EscobarMorreale
Publish Date: 2008/10/02
Volume: 20, Issue: 1, Pages: 69-76
Abstract
We aimed to study serum retinol and αtocopherol in a cohort of obese patients and their possible association with several obesityrelated conditions given that the former may be implicated in a diminished capacity of antiinflammatory and antioxidant potential in obese patientsEighty patients with morbid obesity participated in the study Many clinical and biochemical variables were measured including serum retinol αtocopherol aspartate aminotransferase AST and alanine aminotransferase ALT concentrations Fatty liver was detected by ultrasonographyBoth serum retinol and αtocopherol inversely correlated with body mass index r = −0334 P = 0002 and r = −0299 P = 0007 respectively Serum retinol inversely correlated with AST r = −0236 P = 0036 and ALT r = −0241 P = 0032 Multivariate regression analyses confirmed these results after correcting for the effects of other variables Eightyfive percent of patients had fatty liver When restricting the analysis to them multivariate regression identified male sex β = 0451 P = 0003 age β = −0275 P = 0039 and serum retinol concentrations β = −0414 P = 0005 as predictive variables on serum AST R 2 = 0230 F = 3408 P = 0009 and male sex β = 0448 P = 0003 age β = −0236 P = 0046 insulin resistance determined by homeostasis model assessment β = 0243 P = 0050 and serum retinol concentrations β = −0305 P = 0022 as predictive variables on serum ALT R 2 = 0296 F = 5817 P = 0001Serum retinol and αtocopherol concentrations are inversely associated with body mass index in morbid obesity and serum retinol is also inversely associated with serum concentrations of transaminases in those patients with nonalcoholic fatty liver disease
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