Authors: J Ybarra F BlancoVaca S Fernández A Castellví R Bonet X Palomer J OrdóñezLlanos A Trius R VilaRovira A Pérez
Publish Date: 2008/02/09
Volume: 18, Issue: 4, Pages: 408-414
Abstract
Abdominal fat both visceral and subcutaneous accumulation is associated with an increased risk of developing insulin resistance The latter stands as the basis upon which diabetes hypertension and atherogenic dyslipidemia tend to build up Hence abdominal liposuction AL could theoretically hold metabolic benefits We undertook the present study to assess the effects of AL on carbohydrate and lipid metabolismThis is a prospective study including 20 healthy volunteers M2/F18 aged 396 ± 77 years old 24–52 body mass index BMI = 253 ± 47 kg/m2 198–36 who underwent AL Before and 4 months after AL we measured glucose and insulin concentrations HOMA index glucose mM × IRI μUI/l/225 free fatty acids FFA glycerol total cholesterol and triglycerides highdensity lipoprotein HDLcholesterol HDLc lowdensity lipoprotein LDLcholesterol LDLc very lowdensity lipoprotein VLDLcholesterol VLDLc and apolipoproteins apo B AI and AII adiponectin Adp and ultrasensitive Creactive protein CRPLipoaspirate averaged 5494 ± 5297 cc 600–19000 Weight BMI and waist circumference decreased significantly 4 months after surgery by 46 46 and 59 respectively There were significant decrements in FFA −35 p 00001 glycerol −63 p 00005 VLDLc −152 p 0001 and triglycerides −213 p 0002 an increase in HDLc +10 p 003 Apo AI +101 p 002 and Apo AII +118 p 0001 Total cholesterol LDLc ApoB and the LDLc/ApoB ratio raised by +15 p 00005 +273 p 0000 +151 p 0008 and +276 p 0008 respectively Glucose insulin the HOMA index Adp and CRP were not significantly altered after AL
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