Authors: Fernando GranadoLorencio Alberto SimalAntón Inmaculada BlancoNavarro Teresa GonzálezDominguez Belén PérezSacristán
Publish Date: 2011/04/27
Volume: 21, Issue: 10, Pages: 1605-1611
Abstract
Obesity constitutes a growing health problem and surgical treatment of severe obesity is increasingly used Nutrient deficiencies are common following bariatric surgery and the evidence indicates a progressive increase in the incidence and severity of the deficiency of certain vitamins and related clinical conditions Because of the potential role of carotenoids in disease prevention our aim was to assess the carotenoid status in candidates for obesity surgery and the timecourse changes following two bariatric proceduresSeventyfive candidates for bariatric surgery 17 men 58 women age 43 ± 10 years and a total of 362 serum samples after obesity surgery ie RouxenY gastric bypass n = 187 and biliopancreatic diversion n = 175 were consecutively collected and assessed Retinol α and γtocopherol 25OHvitamin D3 lutein zeaxanthin α and βcryptoxanthin lycopene trans and cis α and βcarotene trans and cis were analyzed by highperformance liquid chromatographyMean serum levels of carotenoids in candidates for obesity surgery were within the reference values reported in controls and seasonal variations were present in several analytes After surgery and regardless of the type of intervention all serum carotenoids dropped following firstorder kinetics Cis/trans ratio of lycopene and βcarotene did not change after surgery over the time or between surgical procedures On a longterm serum carotenoids were at or below fifth percentile of reference groupsThe chronic low levels of carotenoids in these patients compromise their availability to tissues constituting an additional risk factor for other clinical conditions Dietary advice on carotenoidrich fortified foods or supplements should be also evaluated in these patients
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