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Title of Journal: Cell Biochem Biophys

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Abbravation: Cell Biochemistry and Biophysics

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Springer US

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DOI

10.1016/0924-980x(95)92685-f

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1559-0283

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Quantitative Redox Biology An Approach to Underst

Authors: Garry R Buettner Brett A Wagner Victor G J Rodgers
Publish Date: 2011/12/09
Volume: 67, Issue: 2, Pages: 477-483
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Abstract

Systems biology is now recognized as a needed approach to understand the dynamics of inter and intracellular processes Redox processes are at the foundation of nearly all aspects of biology Free radicals related oxidants and antioxidants are central to the basic functioning of cells and tissues They set the cellular redox environment and therefore are the key to regulation of biochemical pathways and networks thereby influencing organism health To understand how shortlived quasistable species such as superoxide hydrogen peroxide and nitric oxide connect to the metabolome proteome lipidome and genome we need absolute quantitative information on all redox active compounds as well as thermodynamic and kinetic information on their reactions ie knowledge of the complete redoxome Central to the state of the redoxome are the interactive details of the superoxide/peroxide formation and removal systems Quantitative information is essential to establish the dynamic mathematical models needed to reveal the temporal evolution of biochemical pathways and networks This new field of Quantitative Redox Biology will allow researchers to identify new targets for intervention to advance our efforts to achieve optimal human healthSupported by Grants R01GM073929 from the NIGMS and P42ES013661 from the NIEHS The content is solely the responsibility of the authors and does not represent views of the NIGMS NIEHS or the NIH The University of Iowa ESR Facility provided invaluable support

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